CALL FOR PAPERS Cardiovascular Aging Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase
نویسندگان
چکیده
Sándor Bátkai,* Mohanraj Rajesh,* Partha Mukhopadhyay,* György Haskó, Lucas Liaudet, Benjamin F. Cravatt, Anna Csiszár, Zoltan Ungvári, and Pál Pacher Sections on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland; Department of Surgery, University of Medicine and Dentistry, New Jersey-New Jersey Medical School, Newark, New Jersey; Department of Intensive Care Medicine, University Hospital, Lausanne, Switzerland; The Skaggs Institute for Chemical Biology and Department of Cell Biology, The Scripps Research Institute, La Jolla, California; and Department of Physiology, New York Medical College, Valhalla, New York
منابع مشابه
Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase.
Recent studies have uncovered important cross talk between inflammation, generation of reactive oxygen and nitrogen species, and lipid metabolism in the pathogenesis of cardiovascular aging. Inhibition of the endocannabinoid anandamide metabolizing enzyme, the fatty acid amide hydrolase (FAAH), is emerging as a promising novel approach for the treatment of various inflammatory disorders. In thi...
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The endocannabinoid anandamide exerts neurobehavioral, cardiovascular, and immune-regulatory effects through cannabinoid receptors (CB). Fatty acid amide hydrolase (FAAH) is an enzyme responsible for the in vivo degradation of anandamide. Recent experimental studies have suggested that targeting the endocannabinergic system by FAAH inhibitors is a promising novel approach for the treatment of a...
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